Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit
供应商
Biovision
产品货号
K310-100
产品报价
¥已停产
产品说明书
购买方式
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产品新闻
背景资料
Angiotensin II converting enzyme (ACE2, EC 3.4.17.23), a carboxypeptidase, is part of the renin-angiotensin system (RAS) that controls regulation of blood pressure by cleaving the C-terminal dipeptide of Angiotensin II to convert it into Angiotensin 1-7. It also cleaves Angiotensin I to produce Ang 1-9, of unknown function. ACE2 is a receptor of human coronaviruses, such as SARS and HCoV-NL63. It is expressed on the vascular endothelial cells of heart and kidney. The inhibitors of ACE2 could be able to regulate hypertension by changing vascular permeability. Screening for small molecule and peptide inhibitors might also help in finding treatment for coronavirus mediated infection. BioVision’s ACE2 Inhibitor Screening Kit can be used to screen for potent inhibitors of ACE2 activity, it utilizes the ability of an active ACE2 to cleave a synthetic MCA based peptide substrate to release a free fluorophore. The released MCA can be easily quantified using a fluorescence microplate reader. In the presence of an ACE2 specific inhibitor, the enzyme loses its peptidase activity which results in decrease of fluorescence intensity. This assay kit is simple and can be used to identify and characterize ACE2 inhibitors in a high-throughput format.
产品描述
该产品血管紧张素II转换酶(ACE2)抑制剂筛选试剂盒又称Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit,是Biovision中国区域总代理中欧体育
科技提供的原装进口产品,具体的产品详情可查阅产品说明书。
产品特点
• Simple and reliable test to screen ACE2 inhibitors/activators
• High-throughput compatible
• Includes Inhibitor Control